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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2001 1
2003 5
2004 5
2005 3
2006 5
2007 10
2008 11
2009 14
2010 13
2011 11
2012 23
2013 27
2014 29
2015 33
2016 30
2017 28
2018 28
2019 24
2020 22
2021 22
2022 6
2023 10
2024 2

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314 results

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Page 1
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes.
Hegdekar N, Sarkar C, Bustos S, Ritzel RM, Hanscom M, Ravishankar P, Philkana D, Wu J, Loane DJ, Lipinski MM. Hegdekar N, et al. Autophagy. 2023 Jul;19(7):2026-2044. doi: 10.1080/15548627.2023.2167689. Epub 2023 Jan 18. Autophagy. 2023. PMID: 36652438 Free PMC article.
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI) contributes to long-term tissue damage and poor functional outcomes. ...Overall, our work demonstrates that inhibition of autophagy in microglia and infiltrating macrophages contributes to exc …
Excessive and prolonged neuroinflammation following traumatic brain injury (TBI) contributes to long-term tissue damage and poor func …
Bioinformatics analysis and in vivo validation of ferroptosis-related genes in ischemic stroke.
Liu C, Li Z, Xi H. Liu C, et al. Front Pharmacol. 2022 Nov 24;13:940260. doi: 10.3389/fphar.2022.940260. eCollection 2022. Front Pharmacol. 2022. PMID: 36506580 Free PMC article.
Four candidate genes enriched in the HIF-1 signaling pathway (HMOX1, STAT3, CYBB, and TLR4) were selected based on the hierarchical clustering of the PPI dataset. ...In addition, dexmedetomidine significantly reduced MCAO-induced cell death, improved neurobehavioral defici …
Four candidate genes enriched in the HIF-1 signaling pathway (HMOX1, STAT3, CYBB, and TLR4) were selected based on the hierarchical c …
Transcriptomic reveals the ferroptosis features of host response in a mouse model of Zika virus infection.
Yan Q, Zheng W, Jiang Y, Zhou P, Lai Y, Liu C, Wu P, Zhuang H, Huang H, Li G, Zhan S, Lao Z, Liu X. Yan Q, et al. J Med Virol. 2023 Jan;95(1):e28386. doi: 10.1002/jmv.28386. J Med Virol. 2023. PMID: 36477858
We investigated the host response features of in vivo replication in a mouse model of ZIKV infection, by performing a series of transcriptomic and bioinformatic analyses of ZIKV and mock-infected brain tissue. Tissue damage, inflammatory cells infiltration and high viral r …
We investigated the host response features of in vivo replication in a mouse model of ZIKV infection, by performing a series of transcriptom …
NADPH Oxidase Subunit CYBB Confers Chemotherapy and Ferroptosis Resistance in Mesenchymal Glioblastoma via Nrf2/SOD2 Modulation.
Su IC, Su YK, Setiawan SA, Yadav VK, Fong IH, Yeh CT, Lin CM, Liu HW. Su IC, et al. Int J Mol Sci. 2023 Apr 22;24(9):7706. doi: 10.3390/ijms24097706. Int J Mol Sci. 2023. PMID: 37175412 Free PMC article.
Public transcriptomic data re-analysis found that CYBB and SOD2 were highly upregulated in the mesenchymal subtype of GBM. ...Mechanistically, CYBB interacted with Nrf2 and consequently regulated SOD2 transcription. ...
Public transcriptomic data re-analysis found that CYBB and SOD2 were highly upregulated in the mesenchymal subtype of GBM. ...Mechani …
Genetic Association and Altered Gene Expression of CYBB in Multiple Sclerosis Patients.
Cardamone G, Paraboschi EM, Soldà G, Duga S, Saarela J, Asselta R. Cardamone G, et al. Biomedicines. 2018 Dec 18;6(4):117. doi: 10.3390/biomedicines6040117. Biomedicines. 2018. PMID: 30567305 Free PMC article.
In this work, we screened for association with MS 11 single nucleotide polymorphisms (SNPs) and two microsatellite markers in the five genes (NCF1, NCF2, NCF4, CYBA, and CYBB) of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX2) system, the enzymatic p …
In this work, we screened for association with MS 11 single nucleotide polymorphisms (SNPs) and two microsatellite markers in the five genes …
Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, Trautmann S, Geisslinger G, Münch C, Fulda S, Tegeder I, Kögel D. Meyer N, et al. Autophagy. 2021 Nov;17(11):3424-3443. doi: 10.1080/15548627.2021.1874208. Epub 2021 Jan 19. Autophagy. 2021. PMID: 33461384 Free PMC article.
The results also support the notion that simultaneous overactivation of autophagy and induction of LMP represents a promising approach for the treatment of GBM.Abbreviations: ACD: autophagic cell death; AKT1: AKT serine/threonine kinase 1; ATG5: autophagy related 5; ATG7: autopha …
The results also support the notion that simultaneous overactivation of autophagy and induction of LMP represents a promising approach for t …
Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats.
Wang J, Liu Y, Shen H, Li H, Wang Z, Chen G. Wang J, et al. Acta Neurochir Suppl. 2020;127:47-54. doi: 10.1007/978-3-030-04615-6_8. Acta Neurochir Suppl. 2020. PMID: 31407062
BACKGROUND: Previously studies have shown that Nox2 and Nox4, as members of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, Nox), participate in brain damage caused by ischemia-reperfusion (I/R). The aim of this study is to investigate the effects of sp …
BACKGROUND: Previously studies have shown that Nox2 and Nox4, as members of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxida …
Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment.
Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT. Qin L, et al. J Neuroinflammation. 2008 Mar 18;5:10. doi: 10.1186/1742-2094-5-10. J Neuroinflammation. 2008. PMID: 18348728 Free PMC article.
Ten daily doses of ethanol increased brain and liver TNFalpha, and pretreatment with ethanol potentiated LPS-induced increases in TNFalpha, MCP-1, IL-1beta in liver, serum and brain. ...IL-10, an anti-inflammatory cytokine, is reduced in brain by ethanol and …
Ten daily doses of ethanol increased brain and liver TNFalpha, and pretreatment with ethanol potentiated LPS-induced increases in TNF …
Abeta initiates brain hypometabolism, network dysfunction and behavioral abnormalities via NOX2-induced oxidative stress in mice.
Malkov A, Popova I, Ivanov A, Jang SS, Yoon SY, Osypov A, Huang Y, Zilberter Y, Zilberter M. Malkov A, et al. Commun Biol. 2021 Sep 9;4(1):1054. doi: 10.1038/s42003-021-02551-x. Commun Biol. 2021. PMID: 34504272 Free PMC article.
A predominant trigger and driver of sporadic Alzheimer's disease (AD) is the synergy of brain oxidative stress and glucose hypometabolism starting at early preclinical stages. ...Our data provide direct experimental evidence for causes and consequences of AD-related bra …
A predominant trigger and driver of sporadic Alzheimer's disease (AD) is the synergy of brain oxidative stress and glucose hypometabo …
Rebalancing NOX2/Nrf2 to limit inflammation and oxidative stress across gut-brain axis in migraine.
Ardizzone A, Capra AP, Repici A, Lanza M, Bova V, Palermo N, Paterniti I, Esposito E. Ardizzone A, et al. Free Radic Biol Med. 2024 Mar;213:65-78. doi: 10.1016/j.freeradbiomed.2024.01.018. Epub 2024 Jan 19. Free Radic Biol Med. 2024. PMID: 38244728 Free article.
Indeed, the constant bidirectional communication between the Central Nervous System (CNS) and the gastrointestinal (GI) tract, known as the gut-brain axis, has become an attractive target involved in different human disorders. ...Moreover, we demonstrated that the decrease …
Indeed, the constant bidirectional communication between the Central Nervous System (CNS) and the gastrointestinal (GI) tract, known as the …
314 results